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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Pragmatic, a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming software is used by the top operators and land based casinos. The company offers front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support, and bug reporting. Additionally, the company provides its users a safe environment that features high-quality graphics and 프라그마틱 gameplay.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and also helps to reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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Legality

Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work with mobile devices and supports multiple languages. It has established itself as one of the leading casino gaming platforms despite its relative infancy. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers to inform their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design and delivery of the intervention, as well as follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of studies were conducted in primary care settings.